Cytotherapy Journal Cover


Aims and Scope

Cytotherapy, the official journal of the International Society of Cell and Gene Therapy (ISCT), publishes novel and innovative results from high quality scientific and clinical studies in the fields of cell and gene therapy. In addition to Short Reports and Full-Length Articles, the journal also accepts Editorials on emerging trends and potential controversies in the field, and Review articles summarizing important areas of cell and gene therapy research that are topical and/or challenge existing paradigms in the field.

Cytotherapy considers manuscripts exploring the following topics:

  • Development and/or characterization of novel gene therapies and cell and/or EV-based therapeutics
  • Design of novel therapeutic approaches employing cell/EV/gene products.
  • Mode of action of cell/EV/gene therapies in relevant cell-based and pre-clinical models.
  • Identification of novel biomarkers that predict the potency of cell/EV/gene therapies and/or stratify patients based on response rates.
  • Role of stem/stromal cells and/or EVs in disease pathophysiology.
  • Early and late phase clinical studies evaluating the safety and efficacy of cell/EV/gene therapies.
  • Important advances in cell/EV/gene-based product manufacturing and validation
  • Global/regional regulatory practices that impact the authorized use and/or regulatory approval of cell/EV and gene therapies.


Cytotherapy does not publish manuscripts on the following topics:

  • Case studies unless they are of unusual significance to the field.
  • Basic/translational studies exploring the role of lncRNAs, circRNAs, and miRNAs in disease pathophysiology
  • Studies describing signaling pathways implicated in cancer

Mission Statement

To be the premier cell and gene therapy translation journal.

Top Cited Articles

Powered by Scopus, most cited articles published since 2012:

1. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)

Journal: Volume 15, Issue 6, June 2013
Authors: Bourin, P.; Bunnell, B.A.; Casteilla, L.; Dominici, M.; Katz, A.J.; March, K.L.; Redl, H.; Rubin, J.P.; Yoshimura, K.; Gimble, J.M.

2. The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

Journal: Volume 15, Issue 1, January 2013
Author: Galipeau, J.

3. Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal

Journal: Volume 15, Issue 9, September 2013
Authors: MSC Committee of the International Society for Cellular Therapy (ISCT); Krampera, M.; Galipeau, J.; Shi, Y.; Tarte, K.; Sensebe, L.

4. Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: Production process, content and identification of active components

Journal: Volume 14, Issue 5, May 2012
Authors: Fekete, N.; Gadelorge, M.; Fürst, D.; Maurer, C.; Dausend, J.; Fleury-Cappellesso, S; Mailnder, V.; Lotfi, R.; Ignatius, A.; Sensebe, L.; Bourin, P. ; Schrezenmeier, H.; Rojewski, M.T. 

5. Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

Journal: Volume 14, Issue 2, February 2012 
Authors: Francois, M.; Copland, I.B.; Yuan, S.; Romieu-Mourez, R.; Waller, E.K.; Galipeau, J.

6. Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: A long-term safety study

Journal: Volume 14, Issue 1, January 2012
Author: Mazzini, L.; Kareschi, K.; Ferrero, I.; Miglioretti, M.; Stecco, A.; Servo, S.; Carriero, A.; Monaco, F.; Fagioli, F. 

7. Risk of tumorigenicity in mesenchymal stromal cell-based therapies - Bridging scientific observations and regulatory viewpoints

Journal: Volume 15, Issue 7, July 2013
Authors: Barkholt, L.; Flory, E.; Jekerle, V.; Lucas-Samuel, S.; Ahnert, P.; Bisset, L.; Buscher, D.; Fibbe, W.; Foussat, A.; Kwa, M.; Lantz, O.; Maciulaitis, R.; Palomaki, T.; Schneider, C.K.; Sensebe, L.; Tachdjian, G.; Tarte, K.; Tosca, L.; Salmikangas, P.

8. Phase I trial: The use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia

Journal: Volume 16, Issue 2, February 2014
Authors: Bura, A., Planat-Benard, V.; Bourin, P.; Silvestre, J.S.; Gross, F.; Grolleau, J.L.; Saint-Lebese, B.; Peyrafitte, J.A.; Fleury, S.; Gadelorge, M.; Taurand, M.; Dupuis-Coronas, S.; Leobon, B.; Casteilla, L.

9. Mesenchymal stromal cells and fibroblasts: A case of mistaken identity?

Journal: Volume 14, Issue 5, May 2012
Author: Hematti, P.

10. Is CD34 truly a negative marker for mesenchymal stromal cells?

Journal: Volume 14, Issue 10, November 2012
Authors: Lin, C.S.; Ning, H.; Lin, G.; Lue, T.F.

Journal Leadership


Edwin M. Horwitz

Emory University School of Medicine
United States

Commissioning Editor

Patrick J. Hanley, PhD

Children's National Hospital
United States

Associate Editors

Oscar Lee, MD, PhD
National Yang Ming Chiao Tung University
Sai-Kiang Lim, PhD 
A*STAR Institute of Molecular and Cell Biology Singapore
Shin Kawamata, MD, PhD
Anna Pasetto, PhD
Karolinska Institutet
Susan Prockop, MD
Boston Children's Hospital
United States
Qasim A. Rafiq, PhD
University College London
United Kingdom
Sowmya Viswanathan, PhD
University Health Network

Assistant Editor

Rachel A. Burga, PhD
Obsidian Therapeutics
United States

About the Journal

The journal's scope includes research in:

  • Stem cell processing and transplantation
  • Cell-based therapies of malignant and non-malignant blood diseases
  • CancerStem cell plasticity
  • Autoimmune diseases
  • Immunotherapy
  • Congenital disorders
  • Novel molecular therapies
  • Gene therapy
  • Microvesicle biology and therapeutic application

Readership and Target Group: Cytotherapy provides essential reading for scientists, physicians, technicians and regulatory experts involved in cell processing and therapy. It is a vital resource for hematologists, oncologists, and immunologists and the growing number of physicians from many disciplines involved in tissue repair and stem cell research, cytokine investigators, cancer biologists and biotherapists.

Keywords: Cytotherapy, Cytokine, Translational Research, Stem Cells, Cellular Therapies, Vaccines, Gene Therapy, Immunotherapy, Tissue Engineering, Blood and Bone Marrow, T cells.

Submit a Manuscript

Cytotherapy publishes original papers, reviews, novel hypotheses, short communications, book reviews and editorials. Submitted manuscripts will be reviewed by at least two reviewers. Authors will be notified within 30 working days of receipt, whether the manuscript is accepted, requires revision, or is rejected. All manuscripts will be published within 5 months from the date of acceptance.

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For questions and issues about accessing Cytotherapy, contact Elizabeth Lam:

Ande Nichols
Publisher, Cytotherapy

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